Do steroid injections to the peripheral nerve increase perineural fibrosis? An animal experimental study

Background/Aim: Perineural fibrosis may be seen in some surgeries after unsuccessful transforaminal injections. This animal experiment aims to investigate the effect of steroids and/or local anesthetic substances used epidural/transforaminal injections on fibrosis. Methods: A total 14 male Wistar-Albino rats were separated into two groups 7. After intraperitoneal anesthesia, right and left sciatic nerves explored all groups. In group 1, appropriate dose methylprednisolone acetate bupivacaine hydrochloride, 2 only was administered nerves. The identified without application any procedure secure control side All areas marked for later sampling. 3 weeks, sacrificed samples taken around nerve histopathological examination. Results: perineural (intervention side) at grade five 0 two. as side, observed 5 rats, not rats. No statistically significant difference defined with respect (P=0.128). 2, 4 one rat, rat. second group, 1 each, between intervention rate (P=0.026). Conclusions: alone determined increase risk development. addition anesthetics steroid injection reduce possibility